(alpha,alpha,alpha-Trifluoro-4-tolyl)acetic acid → [2-(4-Trifluoromethyl-phenyl)-ethyl]-(6-trifluoromethyl-pyridin-3-yl)-amine

HRID 1094377Notes

Reaction equation

HRID 1094377 reaction equation
[F:1][C:2]([F:14])([F:13])[C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10](O)=O)=[CH:5][CH:4]=1.[F:15][C:16]([F:25])([F:24])[C:17]1[N:22]=[CH:21][C:20]([NH2:23])=[CH:19][CH:18]=1>>[F:1][C:2]([F:14])([F:13])[C:3]1[CH:8]=[CH:7][C:6]([CH2:9][CH2:10][NH:23][C:20]2[CH:21]=[N:22][C:17]([C:16]([F:25])([F:15])[F:24])=[CH:18][CH:19]=2)=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 118342(alpha,alpha,alpha-Trifluoro-4-tolyl)acetic acidHCID 27377445-Amino-2-(trifluoromethyl)pyridine

Product 1

HCID 58007513[2-(4-Trifluoromethyl-phenyl)-ethyl]-(6-trifluoromethyl-pyridin-3-yl)-amine

Procedure

In analogy to example 33, step 1, (4-trifluoromethyl-phenyl)-acetic acid (commercially available) was coupled with 6-trifluoromethyl-pyridin-3-ylamine (commercially available) to give the title compound MS m/e: 335.1 [M+H]+.

Sources & evidence

ORD record
ord-fc62bdcb9d5545a6902b6583d4dcb58b
Source dataset
uspto-grants-2012_03
Patent number
US08133909B2

Reaction notes

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