Hydrochloric Acid → HCID 24822776, compound

HRID 1094513Notes

Reaction equation

HRID 1094513 reaction equation
[OH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8]([C:12]([OH:14])=[O:13])=[CH:7][CH:6]=[CH:5]2.[Cl:15][C:16]1[N:21]=[C:20](Cl)[CH:19]=[CH:18][N:17]=1.O.Cl>CC(C)=O.[OH-].[Na+]>[Cl:15][C:16]1[N:21]=[C:20]([O:1][C:2]2[CH:3]=[C:4]3[C:9](=[CH:10][CH:11]=2)[C:8]([C:12]([OH:14])=[O:13])=[CH:7][CH:6]=[CH:5]3)[CH:19]=[CH:18][N:17]=1

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 775312,4-DichloropyrimidineHCID 54638006-Hydroxy-1-naphthoic acid

Product 1

HCID 24822776HCID 24822776, compound

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 14798Sodium HydroxideSolvent

Conditions

Temperature
50 °C

Procedure

To a mixture of 7.4 g (39.5 mMol) 6-hydroxy-1-naphthoic acid and 5.9 g (39.5 mMol) 2,4-dichloropyrimidin in 104 ml of acetone, 79 ml NaOH (1 M in H2O) are added dropwise. The mixture is stirred for 19 h at rt and finally 2 h at 50° C. Then it is poured into 1.3 l water and acidified by addition of 40 ml of a 2 M HCl solution. Filtration of the suspension, washing with water and drying gives the title compound: MS: [M+1]+=301.

Workup

  1. additionare added dropwise
  2. filtrationFiltration of the suspension
  3. washwashing with water
  4. customdrying

Sources & evidence

ORD record
ord-c56ce662cb964cf88f046a3456367a5b
Source dataset
uspto-grants-2012_03
Patent number
US08133886B2

Reaction notes

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