反应详情

A solution of 870 μl (10.2 mMol) oxalyl chloride in 10 ml CH2Cl2 is added to an ice-cooled solution of 1.54 g (5.1 mMol) 6-(6-chloro-pyrimidin-4-yloxy)-isoquinoline-1-carboxylic acid and 10 μl DMF in 75 ml CH2Cl2. The reaction mixture is stirred at room temperature for 1 h. The solvent is then evaporated off under reduced pressure to afford the title compound as a brown solid, which is used directly without further purification.

1. customThe solvent is then evaporated off under reduced pressure