HCID 86630488, compound → HCID 76597821, compound

HRID 1094940Notes

Reaction equation

HRID 1094940 reaction equation
[OH:1][C:2]1[C:3]([C:17](=[N:19][NH:20][C:21]([C:23]2[S:27][C:26]([C:28]([N:30]([CH2:32][CH2:33][C:34]([O:36]C(C)(C)C)=[O:35])[CH3:31])=[O:29])=[CH:25][CH:24]=2)=[O:22])[CH3:18])=[CH:4][S:5][C:6]=1[C:7]1[CH:12]=[CH:11][C:10]([C:13]([F:16])([F:15])[F:14])=[CH:9][CH:8]=1>FC(F)(F)C(O)=O>[OH:1][C:2]1[C:3]([C:17](=[N:19][NH:20][C:21]([C:23]2[S:27][C:26]([C:28]([N:30]([CH2:32][CH2:33][C:34]([OH:36])=[O:35])[CH3:31])=[O:29])=[CH:25][CH:24]=2)=[O:22])[CH3:18])=[CH:4][S:5][C:6]=1[C:7]1[CH:8]=[CH:9][C:10]([C:13]([F:15])([F:14])[F:16])=[CH:11][CH:12]=1

Participants

3

Reactant 1

HCID 86630488HCID 86630488, compound

Product 1

HCID 76597821HCID 76597821, compoundYield 56%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

t-Butyl 3-(5-{1-[4-Hydroxy-5-(4-trifluoromethylphenyl)thiophen-3-yl]ethylidenehydrazinocarbonyl}-N-methylthiophene-2-carboxamido)propionate (30 mg, 0.05 mmol) was stirred with trifluoroacetic acid (300 μL) at room temperature for 15 minutes. The reaction solution was concentrated, and after addition of ether the resulting solid was collected by filtration to give the desired product (yield 56%).

Workup

  1. concentrationThe reaction solution was concentrated
  2. additionafter addition of ether the resulting solid
  3. filtrationwas collected by filtration

Sources & evidence

ORD record
ord-068bef0487fd49e29c7770d5d19970c5
Source dataset
uspto-grants-2012_03
Patent number
US08134013B2

Reaction notes

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