Potassium Carbonate → HCID 57743370, compound

HRID 1095081Notes

Reaction equation

HRID 1095081 reaction equation
[I:1][C:2]1[CH:9]=[C:6]([CH:7]=[O:8])[C:5]([OH:10])=[CH:4][CH:3]=1.[O:11]1[CH2:16][CH2:15][CH:14](OS(C)(=O)=O)[CH2:13][CH2:12]1.C([O-])([O-])=O.[K+].[K+]>CN(C)C=O>[I:1][C:2]1[CH:3]=[CH:4][C:5]([O:10][CH:14]2[CH2:15][CH2:16][O:11][CH2:12][CH2:13]2)=[C:6]([CH:9]=1)[CH:7]=[O:8]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 2526125-IodosalicylaldehydeHCID 11344352Oxan-4-yl methanesulfonate

Product 1

HCID 57743370HCID 57743370, compoundYield 85%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In a manner similar to the method described in example 4a, 5-iodosalicylaldehyde (3 g, 12.1 mmol) (Aldrich) reacted with methanesulfonic acid tetrahydropyran-4-yl ester (4 g, 22 mmol) and K2CO3 in N,N-dimethylformamide to give 5-Iodo-2-(tetrahydro-pyran-4-yloxy)-benzaldehyde as a yellow solid (Yield 3.4 g, 85%).

Sources & evidence

ORD record
ord-846221646b0c438da92db8bd67f74f39
Source dataset
uspto-grants-2012_03
Patent number
US08134001B2

Reaction notes

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