4-Methoxyphenol → HCID 57743277, compound

HRID 1095097Notes

Reaction equation

HRID 1095097 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5](F)=[C:6]([CH:9]=1)[CH:7]=[O:8].[CH3:11][O:12][C:13]1[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][CH:14]=1.C([O-])([O-])=O.[K+].[K+]>CN(C)C(=O)C>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:19][C:16]2[CH:17]=[CH:18][C:13]([O:12][CH3:11])=[CH:14][CH:15]=2)=[C:6]([CH:9]=1)[CH:7]=[O:8]

Participants

5

Reactant 3

HCID 90154-MethoxyphenolHCID 11430Potassium CarbonateHCID 7363275-Bromo-2-fluorobenzaldehyde

Product 1

HCID 57743277HCID 57743277, compoundYield 100.9%

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Procedure

In a manner similar to the method described in Example 50a, 5-bromo-2-fluorobenzaldehyde (2.1 g, 10 mmol) (Alfa) was reacted with 4-methoxyphenol (1.24 g, 10 mmol) and K2CO3 in N,N-dimethylacetamide to give 5-bromo-2-(4-methoxy-phenoxy)-benzaldehyde as a white solid (Yield 3.1 g, 92%).

Sources & evidence

ORD record
ord-84b9636194bf445f96309676bceb2863
Source dataset
uspto-grants-2012_03
Patent number
US08134001B2

Reaction notes

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