Potassium Carbonate → HCID 57743314, compound

HRID 1095128Notes

Reaction equation

HRID 1095128 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5](F)=[C:6]([CH:9]=1)[CH:7]=[O:8].[F:11][C:12]([F:21])([F:20])[C:13]1[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][CH:14]=1.C([O-])([O-])=O.[K+].[K+]>CN(C)C(=O)C>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:19][C:16]2[CH:17]=[CH:18][C:13]([C:12]([F:11])([F:20])[F:21])=[CH:14][CH:15]=2)=[C:6]([CH:9]=1)[CH:7]=[O:8]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 678744-(Trifluoromethyl)phenolHCID 7363275-Bromo-2-fluorobenzaldehyde

Product 1

HCID 57743314HCID 57743314, compoundYield 68%

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Procedure

In a manner similar to the method described in Example 50a, 5-bromo-2-fluorobenzaldehyde (2.1 g, 11 mmol) (Alfa) was reacted with 4-trifluoromethylphenol (1.9 g, 12 mmol)(Aldrich) and K2CO3 in N,N-dimethylacetamide to give 5-bromo-2-(4-trifluoromethyl-phenoxy)-benzaldehyde as a yellow solid (Yield 2.47 g, 68%).

Sources & evidence

ORD record
ord-956c4163acd34d05aacd4e5eca69a479
Source dataset
uspto-grants-2012_03
Patent number
US08134001B2

Reaction notes

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