Potassium Carbonate → HCID 57743256, compound

HRID 1095130Notes

Reaction equation

HRID 1095130 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5](F)=[C:6]([CH:9]=1)[CH:7]=[O:8].[C:11]([C:13]1[CH:14]=[C:15]([OH:19])[CH:16]=[CH:17][CH:18]=1)#[N:12].C([O-])([O-])=O.[K+].[K+]>CN(C)C(=O)C>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:19][C:15]2[CH:14]=[C:13]([CH:18]=[CH:17][CH:16]=2)[C:11]#[N:12])=[C:6]([CH:7]=[O:8])[CH:9]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 133943-CyanophenolHCID 7363275-Bromo-2-fluorobenzaldehyde

Product 1

HCID 57743256HCID 57743256, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 31374DimethylacetamideSolvent

Procedure

In a manner similar to the method described in Example 50a, 5-bromo-2-fluorobenzaldehyde (2.2 g, 11 mmol) (Alfa) was reacted with 3-cyanophenol (1.4 g, 12 mmol)(Aldrich) and K2CO3 in N,N-dimethylacetamide to give 3-(4-bromo-2-formyl-phenoxy)-benzonitrile as a brown solid (Yield 3 g, 100%).

Sources & evidence

ORD record
ord-0d1ed8b524594930b083fd95028d45ab
Source dataset
uspto-grants-2012_03
Patent number
US08134001B2

Reaction notes

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