Acetyl chloride → HCID 66640898, compound

HRID 1095185Notes

Reaction equation

HRID 1095185 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:10][CH:11]2[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]2)=[C:6]([CH:9]=1)[CH:7]=O.[Li+].C[Si]([N-:22][Si](C)(C)C)(C)C.[C:27](Cl)(=[O:29])[CH3:28].Cl[Si:32]([CH3:35])([CH3:34])[CH3:33]>C(N(CC)CC)C>[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:10][CH:11]2[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]2)=[C:6]([CH:7]=[N:22][C:27]([O:29][Si:32]([CH3:35])([CH3:34])[CH3:33])=[CH2:28])[CH:9]=1

Participants

6

Reactant 4

HCID 6367Acetyl chlorideHCID 6397ChlorotrimethylsilaneHCID 2733832Lithium HexamethyldisilazideHCID 57743290HCID 57743290, compound

Product 1

HCID 66640898HCID 66640898, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

In a manner similar to the method described in Example 112b, 5-fluoro-2-(cyclohexyloxy)-benzaldehyde was treated with LHMDS, acetyl chloride, triethylamine and chloro-trimethyl-silane to give the desired compound, which was directly used for the next step.

Sources & evidence

ORD record
ord-3a2fb28f9b744945b145724373558611
Source dataset
uspto-grants-2012_03
Patent number
US08134001B2

Reaction notes

Loading…