反应详情

To a stirred solution of cyclopentanol (Aldrich, 2.58 g, 30 mmol) in methylene chloride (150 mL) at 0° C., Methane sulfonyl chloride (2.55 mL, 33 mmol) and triethyl amine (5.23 mL, 37.5 mmol) were added slowly and the mixture was stirred for 1.5 hrs. The reaction was quenched with water and the mixture was washed with 0.5 N HCl and brine solution. The organic layer was dried with sodium sulfate. Removal of solvent gave a colorless oil. 5.1 g.

1. customThe reaction was quenched with water
2. washthe mixture was washed with 0.5 N HCl and brine solution
3. dry with materialThe organic layer was dried with sodium sulfate
4. customRemoval of solvent
5. customgave a colorless oil