Potassium Carbonate → 2-Cyclopentyloxy-5-fluoro-benzaldehyde

HRID 1095187Notes

Reaction equation

HRID 1095187 reaction equation
[F:1][C:2]1[CH:9]=[C:6]([CH:7]=[O:8])[C:5]([OH:10])=[CH:4][CH:3]=1.[CH:11]1(OS(C)(=O)=O)[CH2:15][CH2:14][CH2:13][CH2:12]1.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[CH:11]1([O:10][C:5]2[CH:4]=[CH:3][C:2]([F:1])=[CH:9][C:6]=2[CH:7]=[O:8])[CH2:15][CH2:14][CH2:13][CH2:12]1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 27373285-FluorosalicylaldehydeHCID 13066113Cyclopentyl methanesulfonate

Product 1

HCID 577432202-Cyclopentyloxy-5-fluoro-benzaldehyde

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In a manner similar to the method described in Example 4a, 5-fluoro salicylaldehyde (Aldrich) reacted with methanesulfonic acid cyclopentyl ester prepared in Example 133a and potassium carbonate in dimethylformamide to give a pale yellow oil.

Workup

  1. customto give a pale yellow oil

Sources & evidence

ORD record
ord-e68a41a8089b4e158f92b7852856277f
Source dataset
uspto-grants-2012_03
Patent number
US08134001B2

Reaction notes

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