Acetyl chloride → HCID 66641157, compound

HRID 1095193Notes

Reaction equation

HRID 1095193 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:10][C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=2)=[C:6]([CH:9]=1)[CH:7]=O.[Li+].C[Si]([N-:23][Si](C)(C)C)(C)C.[C:28](Cl)(=[O:30])[CH3:29].Cl[Si:33]([CH3:36])([CH3:35])[CH3:34]>C(N(CC)CC)C>[F:1][C:2]1[CH:3]=[CH:4][C:5]([O:10][C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=2)=[C:6]([CH:7]=[N:23][C:28]([O:30][Si:33]([CH3:36])([CH3:35])[CH3:34])=[CH2:29])[CH:9]=1

Participants

6

Reactant 4

HCID 6367Acetyl chlorideHCID 6397ChlorotrimethylsilaneHCID 2733832Lithium HexamethyldisilazideHCID 425531895-Fluoro-2-(4-fluorophenoxy)benzaldehyde

Product 1

HCID 66641157HCID 66641157, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

In a manner similar to the method described in Example 112b, 5-fluoro-2-(4-fluoro-phenyloxy)-benzaldehyde (VWR) was treated with LHMDS, acetyl chloride, triethylamine and chloro-trimethyl-silane to give the desired compound, which was directly used for the next step.

Sources & evidence

ORD record
ord-4efba7b8b9ba4c98a6295ae04a44f184
Source dataset
uspto-grants-2012_03
Patent number
US08134001B2

Reaction notes

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