Acetyl chloride → HCID 66641138, compound

HRID 1095196Notes

Reaction equation

HRID 1095196 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([O:9][C:10]2[CH:17]=[CH:16][C:15]([F:18])=[CH:14][C:11]=2[CH:12]=O)=[CH:5][CH:4]=1)#[N:2].[Li+].C[Si]([N-:24][Si](C)(C)C)(C)C.[C:29](Cl)(=[O:31])[CH3:30].Cl[Si:34]([CH3:37])([CH3:36])[CH3:35]>C(N(CC)CC)C>[C:1]([C:3]1[CH:8]=[CH:7][C:6]([O:9][C:10]2[CH:17]=[CH:16][C:15]([F:18])=[CH:14][C:11]=2[CH:12]=[N:24][C:29]([O:31][Si:34]([CH3:37])([CH3:36])[CH3:35])=[CH2:30])=[CH:5][CH:4]=1)#[N:2]

Participants

6

Reactant 4

HCID 6367Acetyl chlorideHCID 6397ChlorotrimethylsilaneHCID 2733832Lithium HexamethyldisilazideHCID 43313256HCID 43313256, compound

Product 1

HCID 66641138HCID 66641138, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

In a manner similar to the method described in Example 112b, 2-(4-cyano-phenyloxy)-5-fluoro-benzaldehyde was treated with LHMDS, acetyl chloride, triethylamine and chloro-trimethyl-silane to give the desired compound, which was directly used for the next step.

Sources & evidence

ORD record
ord-701b87f7b6204a36a050a3e30b870dba
Source dataset
uspto-grants-2012_03
Patent number
US08134001B2

Reaction notes

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