Acetyl chloride → HCID 66640757, compound

HRID 1095198Notes

Reaction equation

HRID 1095198 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([O:9][C:10]2[CH:17]=[CH:16][C:15]([F:18])=[CH:14][C:11]=2[CH:12]=O)=[CH:5][CH:4]=1.[Li+].C[Si]([N-:24][Si](C)(C)C)(C)C.[C:29](Cl)(=[O:31])[CH3:30].Cl[Si:34]([CH3:37])([CH3:36])[CH3:35]>C(N(CC)CC)C>[F:18][C:15]1[CH:16]=[CH:17][C:10]([O:9][C:6]2[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=2)=[C:11]([CH:12]=[N:24][C:29]([O:31][Si:34]([CH3:37])([CH3:36])[CH3:35])=[CH2:30])[CH:14]=1

Participants

6

Reactant 4

HCID 6367Acetyl chlorideHCID 6397ChlorotrimethylsilaneHCID 2733832Lithium HexamethyldisilazideHCID 43313276HCID 43313276, compound

Product 1

HCID 66640757HCID 66640757, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

In a manner similar to the method described in Example 112b, 2-(4-methoxy-phenyloxy)-5-fluoro-benzaldehyde was treated with LHMDS, acetyl chloride, triethylamine and chloro-trimethyl-silane to give the desired compound, which was directly used for the next step.

Sources & evidence

ORD record
ord-a81a550b48c94ed588024b96b2313c03
Source dataset
uspto-grants-2012_03
Patent number
US08134001B2

Reaction notes

Loading…