6-Chloro-1,3-dihydroindol-2-one → HCID 66641200, compound

HRID 1095199Notes

Reaction equation

HRID 1095199 reaction equation
[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][C:7](=[O:11])[NH:8]2)=[CH:4][CH:3]=1.[Cl:12][C:13]1[CH:14]=[CH:15][C:16]([F:21])=[C:17]([CH:20]=1)[CH:18]=O>>[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6](=[CH:18][C:17]3[CH:20]=[C:13]([Cl:12])[CH:14]=[CH:15][C:16]=3[F:21])[C:7](=[O:11])[NH:8]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 7363446-Chloro-1,3-dihydroindol-2-oneHCID 27735865-Chloro-2-fluorobenzaldehyde

Product 1

HCID 66641200HCID 66641200, compound

Procedure

In a manner similar to the methods described in Examples 1a and 1b, 6-chloro-1,3-dihydro-indol-2-one (Aldrich) reacted with 5-chloro-2-fluoro-benzaldehyde to give 6-chloro-3-[1-(5-chloro-2-fluoro-phenyl)-methylidene]-2-oxo-2,3-dihydro-indole, which was subsequently protected with (t-BuOCO)2O and DMAP.

Sources & evidence

ORD record
ord-8b0f707924ca428da06d2b3d350b67e0
Source dataset
uspto-grants-2012_03
Patent number
US08134001B2

Reaction notes

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