Potassium Carbonate → HCID 86631798, compound

HRID 1095203Notes

Reaction equation

[I:1][C:2]1[CH:3]=[CH:4][C:5]([OH:10])=[C:6]([CH:9]=1)[CH:7]=[O:8].[CH:11]1(OS(C)(=O)=O)[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1.C(=O)([O-])[O-].[K+].[K+]>>[I:1][C:2]1[CH:3]=[CH:4][C:5]([O:10][CH:11]2[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]2)=[C:6]([CH:9]=1)[CH:7]=[O:8]

Participants

Reactant 3

HCID 11430Potassium Carbonate

HCID 85308Cyclohexyl methanesulfonate

HCID 2526125-Iodosalicylaldehyde

Product 1

HCID 86631798HCID 86631798, compound

Procedure

In a manner similar to the methods described in Example 128a and 112b, 5-iodo-2-hydroxy-benzaldehyde was reacted with methanesulfonic acid cyclohexyl ester and potassium carbonate to give 5-Iodo-2-(cyclohexyloxy)-benzaldehyde, which was subsequently reacted with LHMDS, acetyl chloride, triethylamine and chloro-trimethyl-silane to give the title compound and directly used for the next step.

Sources & evidence

ORD record: ord-93223e36d0394a768aaaef1baa44de7d
Source dataset: uspto-grants-2012_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08134001B2

Reaction notes

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