Ethyl bromoacetate → HCID 66783960, compound

HRID 1095279Notes

Reaction equation

HRID 1095279 reaction equation
C([CH2:5][O:6][C:7]1[CH:29]=[CH:28][C:10]([C:11]2[O:12][C:13]3[C:18]([C:19](=[O:21])[CH:20]=2)=[C:17]([O:22]C)[C:16]([O:24][CH3:25])=[C:15]([O:26][CH3:27])[CH:14]=3)=[CH:9][CH:8]=1)(OC)=O.OC1C(O)=C(OC)C=C2C=1C(=O)C=C(C1C=CC(OC)=CC=1)O2.BrC[C:55]([O:57][CH2:58][CH3:59])=[O:56].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[C:55]([CH2:25][O:24][C:16]1[C:17]([OH:22])=[C:18]2[C:13](=[CH:14][C:15]=1[O:26][CH3:27])[O:12][C:11]([C:10]1[CH:9]=[CH:8][C:7]([O:6][CH3:5])=[CH:29][CH:28]=1)=[CH:20][C:19]2=[O:21])([O:57][CH2:58][CH3:59])=[O:56]

Participants

6

Reactant 4

HCID 7748Ethyl bromoacetateHCID 11430Potassium CarbonateHCID 30840664H-1-Benzopyran-4-one, 5,6-dihydroxy-7-methoxy-2-(4-methoxyphenyl)-HCID 10363589HCID 10363589, compound

Product 1

HCID 66783960HCID 66783960, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

Similar to the preparation of 4′-(carbmethoxymethoxy)-5,6,7-trimethoxyflavone, the title compound is prepared from a suspension of 5,6-dihydroxy-4′,7-dimethoxyflavone (628 mg, 2 mmol), ethyl bromoacetate (367 mg, 2.2 mmol), and anhydrous potassium carbonate (0.5 g) in acetone (50 ml).

Sources & evidence

ORD record
ord-93352ac36a594f0bb5c2b13f1bb94206
Source dataset
uspto-grants-2012_03
Patent number
US08138165B2

Reaction notes

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