Methanol → HCID 59492371, compound

HRID 1095334Notes

Reaction equation

HRID 1095334 reaction equation
[CH3:1][O:2][C:3](=[O:37])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH2:11][N:12]([CH2:18][CH2:19][CH2:20][N:21]2[C:29](=[O:30])[NH:28][C:27]3[C:22]2=[N:23][C:24]([O:32][CH2:33][CH2:34][CH2:35][CH3:36])=[N:25][C:26]=3[NH2:31])[C:13](=[O:17])[CH2:14][S:15][CH3:16])[CH:6]=1.CO.C1C=C(Cl)C=C(C(OO)=[O:48])C=1>C(Cl)Cl>[CH3:1][O:2][C:3](=[O:37])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([CH2:11][N:12]([CH2:18][CH2:19][CH2:20][N:21]2[C:29](=[O:30])[NH:28][C:27]3[C:22]2=[N:23][C:24]([O:32][CH2:33][CH2:34][CH2:35][CH3:36])=[N:25][C:26]=3[NH2:31])[C:13](=[O:17])[CH2:14][S:15]([CH3:16])=[O:48])[CH:6]=1

Participants

5

Reactant 3

HCID 887MethanolHCID 70297m-Chloroperbenzoic acidHCID 24961699HCID 24961699, compound

Product 1

HCID 59492371HCID 59492371, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The product from example 12 (150 mg) was dissolved in DCM (10 ml) and methanol (2 ml) and mCPBA (0.1 g) added. The mixture was stirred at rt for 3 h then purified by RPHPLC, which afforded the title compound. Yield 50 mg.

Workup

  1. customthen purified by RPHPLC, which

Sources & evidence

ORD record
ord-cdbe42fc07804aa38ca1fae758f6fb8f
Source dataset
uspto-grants-2012_03
Patent number
US08138172B2

Reaction notes

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