Trifluoroacetic acid → HCID 24962427, compound

HRID 1095337Notes

Reaction equation

HRID 1095337 reaction equation
[NH2:1][C:2]1[N:10]=[C:9]([O:11][CH2:12][CH2:13][CH2:14][CH3:15])[N:8]=[C:7]2[C:3]=1[NH:4][C:5](=[O:42])[N:6]2[CH2:16][CH2:17][CH2:18][N:19]([CH2:30][C:31]1[CH:36]=[CH:35][CH:34]=[C:33]([CH2:37][C:38]([O:40][CH3:41])=[O:39])[CH:32]=1)[C:20](=[O:29])[CH2:21]C(OC(C)(C)C)=O.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:41][O:40][C:38](=[O:39])[CH2:37][C:33]1[CH:34]=[CH:35][CH:36]=[C:31]([CH2:30][N:19]([C:20](=[O:29])[CH3:21])[CH2:18][CH2:17][CH2:16][N:6]2[C:5](=[O:42])[NH:4][C:3]3[C:7]2=[N:8][C:9]([O:11][CH2:12][CH2:13][CH2:14][CH3:15])=[N:10][C:2]=3[NH2:1])[CH:32]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86645626HCID 86645626, compound

Product 1

HCID 24962427HCID 24962427, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The product from example 20 step (i) (100 mg) was dissolved in DCM (1 ml) and TFA (0.2 ml) added. The mixture was stirred at rt for 2 h. The solution was washed with saturated aqueous NaHCO3 and dried. The mixture was purified by RPHPLC, which afforded the title compound. Yield 30 mg

Workup

  1. washThe solution was washed with saturated aqueous NaHCO3
  2. customdried
  3. customThe mixture was purified by RPHPLC, which

Sources & evidence

ORD record
ord-81509696744a4faea8f84c0e73108740
Source dataset
uspto-grants-2012_03
Patent number
US08138172B2

Reaction notes

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