反应详情

温度

140 °C

A mixture of 2-pent-1-ynylaniline (0.25 g, 1.57 mmol), copper iodide (30 mg, 0.16 mmol), and N,N-dimethylformamide (6 mL) was heated at 140° C. for 4 hours and concentrated. The crude material was dissolved in diethyl ether, filtered through a layer of CELITE filter aid, and concentrated under reduced pressure. The residue was purified by automated flash chromatography eluting with a gradient of 0-20% ethyl acetate in hexanes to provide 0.20 g of 2-propyl-1H-indole.

1. concentrationconcentrated
2. dissolutionThe crude material was dissolved in diethyl ether
3. filtrationfiltered through a layer of CELITE
4. filtrationfilter aid
5. concentrationconcentrated under reduced pressure
6. customThe residue was purified by automated flash chromatography
7. washeluting with a gradient of 0-20% ethyl acetate in hexanes