HCID 11311595、化合物 → (2S)-2-Amino-3,3-dimethylbutanamide

HRID 1095382ノート

反応式

HRID 1095382 の反応式
[NH2:1][C:2]([C@@H:4]([NH:9]C(=O)OCC1C=CC=CC=1)[C:5]([CH3:8])([CH3:7])[CH3:6])=[O:3]>C1COCC1.[Pd]>[NH2:9][C@H:4]([C:2]([NH2:1])=[O:3])[C:5]([CH3:8])([CH3:7])[CH3:6]

参加物

4

反応物 1

HCID 11311595HCID 11311595、化合物

生成物 1

HCID 11297986(2S)-2-Amino-3,3-dimethylbutanamide収率 98.8%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of benzyl [(1S)-1-(aminocarbonyl)-2,2-dimethylpropyl]carbamate (Step 1, 3.7 g, 14 mmol) in THF (40 mL) was added 10% Pd/C (710 mg). The flask was evacuated and flushed with H2 gas and this process was repeated three times. The flask was filled with H2 gas (4 atm) and stirred for 3 h at rt. Then the reaction mixture was filtered through a pad of Celite and concentrated in vacuo to give the title compound as white solid (crude; 1.8 g)

後処理

  1. customThe flask was evacuated
  2. customflushed with H2 gas
  3. additionThe flask was filled with H2 gas (4 atm)
  4. filtrationThen the reaction mixture was filtered through a pad of Celite
  5. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-aba3201ecb3e45419b5891696bceb331
出典データセット
uspto-grants-2012_03
特許番号
US08138177B2

反応ノート

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