反应详情

温度

60 °C

A mixture of tert-butyl 4-cyano-5-(methylsulfonyl)thiophene-2-carboxylate (2.0 g, 7.0 mmol) and hydrazine hydrate (1.7 mL) in methyl alcohol (30 mL) was stirred at 60° C. for 2 hours. The reaction mixture was diluted with ethyl acetate (100 mL) and washed with water. Organic layer was separated, dried over anhydrous sodium sulfate and evaporated. Through chromatography purification (n-hexane/ethyl acetate 3:2), 1 g of the title compound was thus obtained.

1. washwashed with water
2. customOrganic layer was separated
3. dry with materialdried over anhydrous sodium sulfate
4. customevaporated
5. customThrough chromatography purification (n-hexane/ethyl acetate 3:2), 1 g of the title compound
6. customwas thus obtained