反应详情

Sodium iodide (64 mg, 0.43 mmol) and NaHCO3 (86 mg, 1.03 mmol) were added to a solution of 2-chloro-N-[2-(3-trifluoromethoxy-phenylamino)-ethyl]-propionamide (266 mg, 0.86 mmol) in acetone (20 mL). The reaction mixture was heated at reflux for 72 h, then evaporated. The residue was partitioned between EtOAc and water. The organic layer was dried (MgSO4), filtered, and evaporated. Chromatography (SiO2; heptane/EtOAc gradient) afforded the title compound (156 mg, 66%). Yellow oil, MS: 275.1 (M+H)−.

1. temperatureThe reaction mixture was heated
2. temperatureat reflux for 72 h
3. customevaporated
4. customThe residue was partitioned between EtOAc and water
5. dry with materialThe organic layer was dried (MgSO4)
6. filtrationfiltered
7. customevaporated