Methyl iodide → HCID 59635789, compound

HRID 1096446Notes

Reaction equation

HRID 1096446 reaction equation
[H-].[Na+].[Br:3][C:4]1[CH:9]=[CH:8][N:7]([CH2:10][CH:11]([CH3:14])[CH2:12][OH:13])[C:6](=[O:15])[CH:5]=1.[CH3:16]I>CN(C)C=O>[Br:3][C:4]1[CH:9]=[CH:8][N:7]([CH2:10][CH:11]([CH3:14])[CH2:12][O:13][CH3:16])[C:6](=[O:15])[CH:5]=1

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 59635809HCID 59635809, compound

Product 1

HCID 59635789HCID 59635789, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

NaH (60% in mineral oil, 57 mg) was added to a solution of 4-bromo-1-(3-hydroxy-2-methyl-propyl)-1H-pyridin-2-one (0.53 g) in dimethylformamide (6 mL) chilled in an ice bath. After stirring the solution with cooling for 0.5 h, methyl iodide (110 μL) was added. The cooling bath was removed and the solution was stirred at room temperature overnight. Then, the solution was concentrated under reduced pressure and the residue was diluted with water. The resulting mixture was extracted with ethyl acetate and the combined organic extracts were washed with brine and dried (MgSO4). The solvent was evaporated and the residue was purified by HPLC on reversed phase (acetonitrile/water) to give the title compound as an oil. Yield: 70 mg (30% of theory); Mass spectrum (ESI+): m/z=260/262 (Br) [M+H]+.

Workup

  1. temperaturechilled in an ice bath
  2. temperaturewith cooling for 0.5 h
  3. customThe cooling bath was removed
  4. stirringthe solution was stirred at room temperature overnight
  5. concentrationThen, the solution was concentrated under reduced pressure
  6. additionthe residue was diluted with water
  7. extractionThe resulting mixture was extracted with ethyl acetate
  8. washthe combined organic extracts were washed with brine
  9. dry with materialdried (MgSO4)
  10. customThe solvent was evaporated
  11. customthe residue was purified by HPLC on reversed phase (acetonitrile/water)

Sources & evidence

ORD record
ord-291e6e0f2cbe4c6cb5dc7ddd5b338a53
Source dataset
uspto-grants-2012_03
Patent number
US08138178B2

Reaction notes

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