Oxalyl chloride → HCID 86609824, compound

HRID 1096470Notes

Reaction equation

HRID 1096470 reaction equation
[CH3:1][C:2]1[C:10]([CH3:11])=[C:9]([O:12][CH2:13][C@@H:14]2[CH2:19][N:18]([CH3:20])[C:17]3[CH:21]=[CH:22][CH:23]=[CH:24][C:16]=3[O:15]2)[CH:8]=[CH:7][C:3]=1[C:4](O)=[O:5].C(Cl)(=O)C([Cl:28])=O>CN(C)C=O.COCCOC>[CH3:1][C:2]1[C:10]([CH3:11])=[C:9]([O:12][CH2:13][C@@H:14]2[CH2:19][N:18]([CH3:20])[C:17]3[CH:21]=[CH:22][CH:23]=[CH:24][C:16]=3[O:15]2)[CH:8]=[CH:7][C:3]=1[C:4]([Cl:28])=[O:5]

Participants

5

Reactant 2

HCID 65578Oxalyl chlorideHCID 66782252HCID 66782252, compound

Product 1

HCID 86609824HCID 86609824, compound

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideCatalystHCID 80711,2-DimethoxyethaneSolvent

Conditions

Temperature
40 °C

Procedure

Under argon atmosphere, the compound (400 mg) prepared in Example 9 was dissolved to 1,2-dimethoxyethane (6.0 mL). Anhydrous N,N-dimethylformamide (one drop) and oxalyl chloride (0.22 mL) were added to the reaction mixture, which was stirred for 30 minutes at 40° C. The title compound was obtained by concentrating the reaction mixture.

Sources & evidence

ORD record
ord-a6182be7466649c1a340a18f14d26bd6
Source dataset
uspto-grants-2012_03
Patent number
US08138335B2

Reaction notes

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