Hydrochloric Acid → 5-{4-Oxospiro[chroman-2,4'-piperidin]-6-yl}nicotinic acid di-hydrochloride

HRID 1096920노트

반응식

HRID 1096920 반응식
C([O:5][C:6](=[O:36])[C:7]1[CH:12]=[C:11]([C:13]2[CH:14]=[C:15]3[C:32](=[CH:33][CH:34]=2)[O:31][C:18]2([CH2:23][CH2:22][N:21](C(OC(C)(C)C)=O)[CH2:20][CH2:19]2)[CH2:17][C:16]3=[O:35])[CH:10]=[N:9][CH:8]=1)(C)(C)C.[ClH:37]>C(Cl)(Cl)Cl.O1CCOCC1>[ClH:37].[ClH:37].[O:35]=[C:16]1[C:15]2[C:32](=[CH:33][CH:34]=[C:13]([C:11]3[CH:10]=[N:9][CH:8]=[C:7]([CH:12]=3)[C:6]([OH:36])=[O:5])[CH:14]=2)[O:31][C:18]2([CH2:23][CH2:22][NH:21][CH2:20][CH2:19]2)[CH2:17]1

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 579309795-{1'-Tert-butoxycarbonyl-4-oxospiro[chroman-2,4'-piperidin]-6-yl}nicotinic acid tert-butyl ester

생성물 1

HCID 666494905-{4-Oxospiro[chroman-2,4'-piperidin]-6-yl}nicotinic acid di-hydrochloride

시약·촉매·용매 2

HCID 6212Chloroform용매HCID 312751,4-Dioxane용매

실험 절차

5-{1′-tert-butoxycarbonyl-4-oxospiro[chroman-2,4′-piperidin]-6-yl}nicotinic acid tert-butyl ester (14.0 g, 28.3 mmol) was dissolved in CHCl3 (70 mL) and 4N HCl in dioxane (210 mL) was added thereto, and stirred at room temperature for 20 h. The resulted precipitate was filtered and washed with CHCl3 and Et2O to afford 5-{4-oxospiro[chroman-2,4′-piperidin]-6-yl}nicotinic acid di-hydrochloride as a colorless solid.

후처리

  1. filtrationThe resulted precipitate was filtered
  2. washwashed with CHCl3 and Et2O

출처 및 근거

ORD 기록
ord-fcb54009207142dab0aafcf7c67ce897
출처 데이터셋
uspto-grants-2012_03
특허 번호
US08138197B2

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