反应详情

Phenylboronic acid (326 mg), PdCl2(PPh3)2 (84 mg) and cesium carbonate (3.9 g) were added in that order to a THF (10 mL) solution of 2,6-dichloropyridine-4-carboxylic acid (500 mg), and stirred under heat with refluxing for 1.5 hours. The reaction liquid was filtered through Celite, concentrated under reduced pressure, and the residue was purified through silica gel column chromatography (hexane/ethyl acetate) to obtain a crude product of the title compound as a yellow oil. Not purified, this was used in the next step.

1. temperatureunder heat
2. temperaturewith refluxing for 1.5 hours
3. customThe reaction liquid
4. filtrationwas filtered through Celite
5. concentrationconcentrated under reduced pressure
6. customthe residue was purified through silica gel column chromatography (hexane/ethyl acetate)