反应详情

温度

50 °C

Aqueous 2 N sodium hydroxide solution (1.26 mL) was added to an MeOH (5 mL) solution of methyl 3-pyrrolidin-1-yl-5-(tetrazol-5-yl)benzoate (35.6 mg), and stirred at 50° C. for 2 hours and 30 minutes. With cooling with ice, 2 N hydrochloric acid (2.52 mL) and water were added to it, and the formed precipitate was taken out through filtration, washed with water and dried to obtain the title compound as a yellow powder.

1. additionwere added to it
2. filtrationthe formed precipitate was taken out through filtration
3. washwashed with water
4. customdried