Hydrochloric Acid → HCID 178524188, compound

HRID 1096969Notes

Reaction equation

HRID 1096969 reaction equation
[OH-].[Na+].CO.[N:5]1([C:10]2[CH:11]=[C:12]([CH:17]=[C:18]([C:20]3[NH:24][N:23]=[N:22][N:21]=3)[CH:19]=2)[C:13]([O:15]C)=[O:14])[CH2:9][CH2:8][CH2:7][CH2:6]1.Cl>O>[N:5]1([C:10]2[CH:11]=[C:12]([CH:17]=[C:18]([C:20]3[NH:24][N:23]=[N:22][N:21]=3)[CH:19]=2)[C:13]([OH:15])=[O:14])[CH2:6][CH2:7][CH2:8][CH2:9]1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 14798Sodium HydroxideHCID 178497411HCID 178497411, compound

Product 1

HCID 178524188HCID 178524188, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
50 °C

Procedure

Aqueous 2 N sodium hydroxide solution (1.26 mL) was added to an MeOH (5 mL) solution of methyl 3-pyrrolidin-1-yl-5-(tetrazol-5-yl)benzoate (35.6 mg), and stirred at 50° C. for 2 hours and 30 minutes. With cooling with ice, 2 N hydrochloric acid (2.52 mL) and water were added to it, and the formed precipitate was taken out through filtration, washed with water and dried to obtain the title compound as a yellow powder.

Workup

  1. additionwere added to it
  2. filtrationthe formed precipitate was taken out through filtration
  3. washwashed with water
  4. customdried

Sources & evidence

ORD record
ord-ae5be70a46be4899abe8093537d39ee1
Source dataset
uspto-grants-2012_03
Patent number
US08138197B2

Reaction notes

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