Hydrochloric Acid → HCID 57930907, compound

HRID 1096986Notes

Reaction equation

HRID 1096986 reaction equation
[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([CH:11]=[C:12]([O:20][CH3:21])[C:13]=1[C:14]1[CH:15]=[N:16][N:17]([CH3:19])[CH:18]=1)[C:7]([O:9]C)=[O:8])[CH3:2].Cl>CO.C1COCC1.[OH-].[Na+]>[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([CH:11]=[C:12]([O:20][CH3:21])[C:13]=1[C:14]1[CH:15]=[N:16][N:17]([CH3:19])[CH:18]=1)[C:7]([OH:9])=[O:8])[CH3:2]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 57930893HCID 57930893, compound

Product 1

HCID 57930907HCID 57930907, compound

Reagents, catalysts & solvents 2

HCID 14798Sodium HydroxideSolventHCID 21899815MeOH tetrahydrofuranSolvent

Procedure

Methyl 3-ethoxy-5-methoxy-4-(1-methyl-1H-pyrazol-4-yl)benzoate (157 mg) was dissolved in a mixed solvent of methanol/THF (9 mL, 1/2), and aqueous 1 M NaOH solution (2.1 mL) was added to it and stirred at room temperature for 5 hours. Aqueous 1 M HCl solution (2.1 mL) was added to it, and the solvent was concentrated under reduced pressure. The obtained solid was removed through filtration, washed with water and ether, and dried under reduced pressure to obtain the title compound as a white solid.

Workup

  1. additionwas added to it
  2. concentrationthe solvent was concentrated under reduced pressure
  3. customThe obtained solid was removed through filtration
  4. washwashed with water and ether
  5. customdried under reduced pressure

Sources & evidence

ORD record
ord-5da01bf683ba495d9e3c18214460b7e4
Source dataset
uspto-grants-2012_03
Patent number
US08138197B2

Reaction notes

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