反应详情

温度

80 °C

In a 1.0-liter egg plant-type flask, POCl3 (56 mL, 0.60 mL) was dropwise added to a DMF (17.4 mL, 0.23 mol) solution of 3-methyl-1-pyridin-2-yl-1H-pyrazol-5-ol with cooling with ice, and stirred overnight at 80° C. The reaction solution was poured onto crushed ice, and stirred at room temperature. The formed precipitate was filtered, and dried under reduced pressure to obtain the title compound as a pale brown solid.

1. temperaturewith cooling with ice
2. additionThe reaction solution was poured
3. customonto crushed ice
4. stirringstirred at room temperature
5. filtrationThe formed precipitate was filtered
6. customdried under reduced pressure