Hydrochloric Acid → HCID 178434226, compound

HRID 1097005Notes

Reaction equation

HRID 1097005 reaction equation
C([N:4]1[C:12]2[C:7](=[CH:8][C:9]([Br:13])=[CH:10][CH:11]=2)[C:6]([CH3:14])=[N:5]1)(=O)C.[ClH:15]>CO>[ClH:15].[Br:13][C:9]1[CH:8]=[C:7]2[C:12](=[CH:11][CH:10]=1)[NH:4][N:5]=[C:6]2[CH3:14]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 591273821-(5-Bromo-3-methyl-1H-indazol-1-yl)ethan-1-one

Product 1

HCID 178434226HCID 178434226, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
60 °C

Procedure

1-Acetyl-5-bromo-3-methyl-1H-indazole (1.23 g) was added to the solution of hydrochloride in methanol (30 ml), and stirred for 30 min at 60° C. The mixture was concentrated under reduced pressure, and the residue was crystallized from mixed solvent of hexane and EtOAc to give the title compound as a yellow solid.

Workup

  1. concentrationThe mixture was concentrated under reduced pressure
  2. customthe residue was crystallized
  3. additionfrom mixed solvent of hexane and EtOAc

Sources & evidence

ORD record
ord-2a8746bc7f0f4de9985697c071cabdf6
Source dataset
uspto-grants-2012_03
Patent number
US08138197B2

Reaction notes

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