Water → HCID 178508255, compound

HRID 1097323Notes

Reaction equation

HRID 1097323 reaction equation
[NH2:1][C:2]1[NH:7][C:6]([S:8][CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[N:5][C:4](=[O:16])[C:3]=1[S:17][C:18]#[N:19].O>CN(C)C=O>[NH2:19][C:18]1[S:17][C:3]2[C:4](=[O:16])[N:5]=[C:6]([S:8][CH2:9][C:10]3[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=3)[NH:7][C:2]=2[N:1]=1

Participants

4

Reactant 2

HCID 962WaterHCID 178514143HCID 178514143, compound

Product 1

HCID 178508255HCID 178508255, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

The product of example 1 step a) (7.35 g) was heated at 120° C. in N,N-dimethylformamide (40 ml)/water (10 ml) for 10 hours. After cooling, the resulting solid was filtered off, washed with water, then ethyl acetate to give the subtitle compound.

Workup

  1. temperatureAfter cooling
  2. filtrationthe resulting solid was filtered off
  3. washwashed with water

Sources & evidence

ORD record
ord-edc8f84e772f4cd7b6442348ad29fbf1
Source dataset
uspto-grants-2012_03
Patent number
US08143261B2

Reaction notes

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