反应详情

Benzoyl chloride (0.30 ml, 2.58 mmol) is added dropwise to a solution of 2,3-dihydro-1H-quinolin-4-one (260 mg, 1.77 mmol), triethylamine (0.32 ml, 2.30 mmol) and DMAP (10 mg) in CH2Cl2 at 0° C. The resulting mixture is stirred at room temperature for overnight. Water is added and the mixture is extracted with CH2Cl2 and washed with brine, dried over anhydrous sodium sulfate. After concentration, a residue is yielded, which is used “as is” for the next reaction without further purification.

1. extractionthe mixture is extracted with CH2Cl2
2. washwashed with brine
3. dry with materialdried over anhydrous sodium sulfate
4. concentrationAfter concentration
5. customa residue is yielded
6. customfor the next reaction
7. customwithout further purification