Hydrochloric Acid → HCID 24987660, compound

HRID 1097844Notes

Reaction equation

HRID 1097844 reaction equation
C(O[C:6](=O)[N:7]([CH2:9][CH2:10][N:11]1[C:19]2[C:14](=[CH:15][CH:16]=[C:17]([Cl:20])[CH:18]=2)[C:13]([C:21]([N:23]2[CH2:28][CH2:27][CH:26]([N:29]3[C:37]4[C:32](=[CH:33][CH:34]=[CH:35][CH:36]=4)[CH2:31][C:30]3=[O:38])[CH2:25][CH2:24]2)=[O:22])=[CH:12]1)C)(C)(C)C.Cl>CO>[ClH:20].[Cl:20][C:17]1[CH:18]=[C:19]2[C:14]([C:13]([C:21]([N:23]3[CH2:28][CH2:27][CH:26]([N:29]4[C:37]5[C:32](=[CH:33][CH:34]=[CH:35][CH:36]=5)[CH2:31][C:30]4=[O:38])[CH2:25][CH2:24]3)=[O:22])=[CH:12][N:11]2[CH2:10][CH2:9][NH:7][CH3:6])=[CH:15][CH:16]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66811008(2-{6-Chloro-3-[4-(2-oxo-2,3-dihydro-indol-1-yl)-piperidine-1-carbonyl]-indol-1-yl}-ethyl)-methyl-carbamic acid tert-butyl ester

Product 1

HCID 24987660HCID 24987660, compoundYield 191.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 0.25 g (0.45 mmol) (2-{6-chloro-3-[4-(2-oxo-2,3-dihydro-indol-1-yl)-piperidine-1-carbonyl]-indol-1-yl}-ethyl)-methyl-carbamic acid tert-butyl ester in 3.6 ml (4.5 mmol) of a 1.25 M solution of hydrochloric acid in methanol was stirred for 20 min. at 50° C. The reaction mixture was concentrated to dryness to give 0.21 g of the title compound as an off-white solid.

Workup

  1. concentrationThe reaction mixture was concentrated to dryness

Sources & evidence

ORD record
ord-51a8fb37aed44c60bd5d5ed664a2cc91
Source dataset
uspto-grants-2012_03
Patent number
US08143281B2

Reaction notes

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