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Trimethylaluminium (2M in hexanes) (1.839 mL, 3.68 mmol) was added to 6-aminonicotinonitrile (CAS no. 4214-73-7) (411 mg, 3.45 mmol) in DCM (8 mL) cooled to 0° C. under nitrogen. The resulting solution was stirred at 0° C. for 20 minutes. (2S)-methyl 3-((R)-1-(tert-butyldimethylsilyloxy)propan-2-yloxy)-2-(1-(3-chloropyridin-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-yloxy)propanoate (Intermediate AN2) (600 mg, 1.15 mmol) in toluene (8 mL) was added and the reaction was allowed to warm to room temperature and then heated to 100° C. for 5 hours in the microwave reactor. The reaction was allowed to cool to room temperature before adding EtOAc (50 mL) and 20% sodium potassium tartrate solution (30 mL), which was stirred vigorously for 16 hours. The phases were separated and the organic layer was washed with sat. brine (15 mL), dried (MgSO4) and evaporated. The crude product was purified by flash alumina chromatography, eluting with 0 to 50% EtOAc in isohexane to afford the product (395 mg, 56.4%). 1H NMR (400 MHz, DMSO) δ-0.01 (d, 6H), 0.80 (s, 9H), 1.08 (d, 3H), 3.47-3.62 (m, 2H), 3.67-3.77 (m, 1H), 4.09-4.21 (m, 2H), 5.92-5.97 (m, 1H), 7.75-7.80 (m, 1H), 8.13-8.17 (m, 1H), 8.22-8.29 (m, 1H), 8.34-8.37 (m, 1H), 8.58 (s, 1H), 8.63 (s, 1H), 8.67-8.71 (m, 1H), 8.82-8.85 (m, 1H), 11.55 (s, 1H); m/z (ES+), (M+H)+=607.47; HPLC tR=3.27 min

1. temperatureto warm to room temperature
2. temperatureheated to 100° C. for 5 hours in the microwave reactor
3. temperatureto cool to room temperature
4. stirringwas stirred vigorously for 16 hours
5. customThe phases were separated
6. washthe organic layer was washed with sat. brine (15 mL)
7. dry with materialdried (MgSO4)
8. customevaporated
9. customThe crude product was purified by flash alumina chromatography
10. washeluting with 0 to 50% EtOAc in isohexane