反应详情

温度

50 °C

6-bromo-1H-pyrrolo[2,3-b]pyridine (587, 275 mg, 1.39 mmol) was dissolved in 4 mL of dry dioxane. DIEA (3 equiv) and TIPS-OTf (2.5 equiv) were added and the reaction was stirred at 50° C. overnight. The reaction was then diluted with 20 mL of ethyl acetate and washed 2 times with 10 mL NaHCO3 (aq., 5%) and once with 10 mL brine. The organic fraction was dried over MgSO4, evaporated and diluted with 5.5 mL of dry toluene 10 mg bromide per 0.2 mL of solution) to use directly in the next reaction step.

1. washwashed 2 times with 10 mL NaHCO3 (aq., 5%)
2. dry with materialThe organic fraction was dried over MgSO4
3. customevaporated
4. additiondiluted with 5.5 mL of dry toluene 10 mg bromide per 0.2 mL of solution)
5. customto use directly in the next reaction step