Lithium Hydroxide → 1-Isopropyl-3-methyl-1H-pyrazole-4-carboxylic acid

HRID 1098575Notes

Reaction equation

[CH:1]([N:4]1[CH:8]=[C:7]([C:9]([O:11]CC)=[O:10])[C:6]([CH3:14])=[N:5]1)([CH3:3])[CH3:2].[OH-].[Li+]>>[CH:1]([N:4]1[CH:8]=[C:7]([C:9]([OH:11])=[O:10])[C:6]([CH3:14])=[N:5]1)([CH3:3])[CH3:2]

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 66728958HCID 66728958, compound

Product 1

HCID 142779111-Isopropyl-3-methyl-1H-pyrazole-4-carboxylic acidYield 79%

Procedure

In a procedure analogous to Example B6, ethyl 1-isopropyl-3-methyl-1H-pyrazole-4-carboxylate from Example B14 (91 mg, 0.464 mmol) and lithium hydroxide (78 mg, 1.855 mmol) were combined to afford 1-isopropyl-3-methyl-1H-pyrazole-4-carboxylic acid (62 mg, 79% yield). MS (ESI) m/z: 169.0 (M+H+).

Sources & evidence

ORD record: ord-2a0533e944884df2a89b5bd36ced8ab3
Source dataset: uspto-grants-2012_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08143293B2

Reaction notes

Loading…