Sodium borohydride → HCID 59339623, compound

HRID 1098995Notes

Reaction equation

HRID 1098995 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:11](=[O:22])[C@H:12]([NH:14][C:15](=[O:21])[O:16][C:17]([CH3:20])([CH3:19])[CH3:18])[CH3:13])[CH:6]=[CH:7][C:8]=1[S:9][CH3:10].[BH4-].[Na+]>C1COCC1>[OH:22][CH:11]([C:5]1[CH:6]=[CH:7][C:8]([S:9][CH3:10])=[C:3]([O:2][CH3:1])[CH:4]=1)[C@H:12]([NH:14][C:15](=[O:21])[O:16][C:17]([CH3:18])([CH3:19])[CH3:20])[CH3:13]

Participants

4

Reactant 2

HCID 4311764Sodium borohydrideHCID 59339877HCID 59339877, compound

Product 1

HCID 59339623HCID 59339623, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a stirred solution of (R)-t-butyl 1-(3-methoxy-4-(methylthio)phenyl)-1-oxopropan-2-ylcarbamate (308d, 55 μg, 170 μmol) in THF (2 mL) at r.t. was added sodium tetrahydroborate (48 μg, 1.27 mmol) in small portions, and the mixture was stirred for 3 h.

Sources & evidence

ORD record
ord-4ce661f49423428f8051fdec38677d72
Source dataset
uspto-grants-2012_03
Patent number
US08143290B2

Reaction notes

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