Hydrazine hydrate (1:1) → Methyl 4-(3-hydrazino-1,2,4-triazin-6-yl)benzoate

HRID 1099076Notes

Reaction equation

HRID 1099076 reaction equation
Cl[C:2]1[N:3]=[N:4][C:5]([C:8]2[CH:17]=[CH:16][C:11]([C:12]([O:14][CH3:15])=[O:13])=[CH:10][CH:9]=2)=[CH:6][N:7]=1.O.[NH2:19][NH2:20]>O1CCCC1>[NH:19]([C:2]1[N:3]=[N:4][C:5]([C:8]2[CH:17]=[CH:16][C:11]([C:12]([O:14][CH3:15])=[O:13])=[CH:10][CH:9]=2)=[CH:6][N:7]=1)[NH2:20]

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 59216349Methyl 4-(3-chloro-1,2,4-triazin-6-yl)benzoate

Product 1

HCID 59216328Methyl 4-(3-hydrazino-1,2,4-triazin-6-yl)benzoate

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of methyl 4-(3-chloro-1,2,4-triazin-6-yl)benzoate (1.1 g, 0.0044 mol) in tetrahydrofuran (30 mL) was added hydrazine hydrate (1.1 mL, 0.022 mol) at RT with stirring. The mixture was stirred at RT for 1 h, and concentrated under reduced pressure to give the desired product (quantitatively). Analytical LCMS: (M+H)+=245.9.

Workup

  1. stirringThe mixture was stirred at RT for 1 h
  2. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-7e6942761de149ca818f0f303544e7f1
Source dataset
uspto-grants-2012_03
Patent number
US08143251B2

Reaction notes

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