反应详情

温度

87.5 °C

To a clear solution of 5-Methyl-indan-4-ol (6 gm, 0.0405 mole) in 30 ml Trifluoroacetic acid, Hexamine (5.7 gm, 0.0405 mole) was added at 25-28° C. The reaction mixture was heated and stirred at 85-90° C. for 6 hours. The cooled reaction mixture was poured into saturated Sodium bicarbonate solution and extracted with Ethylacetate (2×200 ml). The organic layer was dried over Sodium sulphate and distilled under vacuum to give a crude product which was purified by column chromatography using Ethyl acetate:Hexane (10:90) as mobile phase The collected fractions were distilled to give 5.4 gm of desired product as a solid.

1. temperatureThe reaction mixture was heated
2. customThe cooled reaction mixture
3. extractionextracted with Ethylacetate (2×200 ml)
4. dry with materialThe organic layer was dried over Sodium sulphate
5. distillationdistilled under vacuum
6. customto give a crude product which
7. customwas purified by column chromatography
8. distillationwere distilled