反应详情

温度

26.5 °C

To a stirred suspension of 4-Hydroxy-indan-5-carbaldehyde (52.0 gm, 0.320 mole) and Potassium carbonate (57.2 gm, 0.414 mole) in Dimethylformamide (200 ml) solution of Methyl iodide (22 ml, 0.351 mole) in 60 ml Dimethylformamide was added at 0-5° C. The reaction mixture was stirred at 25-28° C. for 4 hours and then poured into water (200 ml), further it was extracted with Ethyl acetate (2×500 ml). The organic layer was dried over Sodium sulphate, distilled under vacuum to give crude product which was purified through column chromatography using Ethyl acetate:Hexane (3:97) as mobile phase. The collected fractions were distilled under vacuum to give 30 gm of desired product as a viscous oil.

1. additionwas added at 0-5° C
2. extractionwas extracted with Ethyl acetate (2×500 ml)
3. dry with materialThe organic layer was dried over Sodium sulphate
4. distillationdistilled under vacuum
5. customto give crude product which
6. customwas purified through column chromatography
7. distillationThe collected fractions were distilled under vacuum