Iodine I-131 → HCID 59354918, compound

HRID 1099462Notes

Reaction equation

HRID 1099462 reaction equation
[131I][131I].[CH3:3][C:4]1[C:5]([C:9]([O:11][CH2:12][CH3:13])=[O:10])=[N:6][NH:7][N:8]=1.[CH3:14][O:15][CH2:16][CH2:17]Br>>[CH3:14][O:15][CH2:16][CH2:17][N:7]1[N:6]=[C:5]([C:9]([O:11][CH2:12][CH3:13])=[O:10])[C:4]([CH3:3])=[N:8]1

Participants

4

Reactant 3

HCID 24855Iodine I-131HCID 78046Ethyl 5-methyl-1H-1,2,3-triazole-4-carboxylateHCID 809722-Bromoethyl methyl ether

Product 1

HCID 59354918HCID 59354918, compoundYield 54%

Procedure

The title compound was synthesized as described for Intermediate example I-131 in 54% yield starting from ethyl 5-methyl-2H-1,2,3-triazole-4-carboxylate and 2-bromoethyl methyl ether; 1H NMR (400 MHz, CDCl3) δ ppm 4.58 (t, 2 H), 4.42 (q, 2 H), 3.90 (t, 2 H), 3.35 (s, 3 H), 2.49-2.56 (m, 3 H), 1.34-1.46 (m, 3 H); MS (ESI) m/z 214[M+H+].

Sources & evidence

ORD record
ord-c275fe5877514ec28f148afc5ac4099e
Source dataset
uspto-grants-2012_03
Patent number
US08143408B2

Reaction notes

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