反应详情

Voriconazole (1R)-(−)-10-camphorsulfonate (6 g, 10.3 mmol) was suspended in ethyl acetate (18 ml) and treated slowly with aqueous saturated solution of sodium bicarbonate (14.4 ml). The mixture was stirred for 10 minutes and allowed to settle. The organic phase was separated and the aqueous phase was re-extracted with ethyl acetate (13.5 ml). The combined organic phases were washed with deionised water (1.8 ml), filtered through paper and concentrated under reduced pressure to give a white solid (3.28 g, 91.11% yield).

1. customThe organic phase was separated
2. extractionthe aqueous phase was re-extracted with ethyl acetate (13.5 ml)
3. washThe combined organic phases were washed with deionised water (1.8 ml)
4. filtrationfiltered through paper
5. concentrationconcentrated under reduced pressure