Bromide ion → 6-chloro-4-cyclopropyl-4-(4-bromophenyl)-3-(2,2,2-trifluoroethyl)-3,4-dihydroquinazolin-2(1H)-one
Reaction equation
[Br-:37].[CH2:42]1[O:43][CH2:44][CH2:45][CH2:46]1.[CH3:26][CH2:27][N:28]([CH2:29][CH3:30])[CH2:31][CH3:32].[CH:38]1([Mg+:41])[CH2:39][CH2:40]1.[Cl:1][c:2]1[cH:3][c:4]2[c:9]([cH:10][cH:11]1)[NH:8][C:7](=[O:12])[N:6]([CH2:13][C:14]([F:15])([F:16])[F:17])[C:5]2([OH:18])[c:19]1[cH:20][cH:21][c:22]([Br:25])[cH:23][cH:24]1.[S:33]([Cl:34])([Cl:35])=[O:36]>>[Cl:1][c:2]1[cH:3][c:4]2[c:9]([cH:10][cH:11]1)[NH:8][C:7](=[O:12])[N:6]([CH2:13][C:14]([F:15])([F:16])[F:17])[C:5]2([c:19]1[cH:20][cH:21][c:22]([Br:25])[cH:23][cH:24]1)[CH:38]1[CH2:39][CH2:40]1Participants
7
Reactant 6
Product 1
Sources & evidence
- ORD record
- ord-bb127d768ae940b9ab616dbe9390d228
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (2/10)
Reaction notes
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