Acetyl bromide → N-Formyl-2-(4-acetylphenyl)-1,1-dimethylethanamine

HRID 1105635Notes

Reaction equation

HRID 1105635 reaction equation
[Cl-].[Al+3].[Cl-].[Cl-].[C:5](Br)(=[O:7])[CH3:6].[CH:9]([NH:11][C:12]([CH3:21])([CH3:20])[CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[O:10]>ClCCCl>[CH:9]([NH:11][C:12]([CH3:21])([CH3:20])[CH2:13][C:14]1[CH:19]=[CH:18][C:17]([C:5](=[O:7])[CH3:6])=[CH:16][CH:15]=1)=[O:10]

Participants

5

Reactant 3

HCID 10482Acetyl bromideHCID 104077N-(1,1-Dimethyl-2-phenylethyl)formamideHCID 6451240Aluminum(III) Chloride

Product 1

HCID 20556097N-Formyl-2-(4-acetylphenyl)-1,1-dimethylethanamine

Reagents, catalysts & solvents 1

HCID 111,2-DichloroethaneSolvent

Procedure

This was prepared in an identical manner to the compound described in Description 10 using aluminum chloride (26 g), acetyl bromide (115 ml) and N-formyl-2-phenyl-1, 1-dimethylethanamine (101.5 g) in 1,2-dichloroethane, (850 ml). τ(CDCl3). 8.62 (6H, s), 7.45 (3H, s), 7.1+6.85 (2H, s+s), 3.85 (1H, broad) 2.7 (2H, d, J=8 Hz) 2.1 (2H, d, J=8 Hz), 1.9 (1H, s).

Workup

  1. customThis was prepared in an identical manner to the compound

Sources & evidence

ORD record
ord-c216a8b6494248a882b98526218a7ea6
Source dataset
uspto-grants-1982_01
Patent number
US04309443

Reaction notes

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