HCID 15564129, compound → HCID 15564114, compound

HRID 1105661Notes

Reaction equation

HRID 1105661 reaction equation
Cl.[Br:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([NH2:17])=[NH:16])=[CH:11][CH:10]=2)=[CH:5][CH:4]=1>CC[O-].[Na+]>[CH2:9]([C:6]1[CH:5]=[N:16][C:15]([C:12]2[CH:13]=[CH:14][C:9]([C:6]3[CH:5]=[CH:4][C:3]([Br:2])=[CH:8][CH:7]=3)=[CH:10][CH:11]=2)=[N:17][CH:7]=1)[CH2:10][CH2:11][CH2:12][CH3:13]

Participants

3

Reactant 1

HCID 15564129HCID 15564129, compound

Product 1

HCID 15564114HCID 15564114, compound

Reagents, catalysts & solvents 1

HCID 2723922Sodium ethoxideSolvent

Procedure

1.42 G. of the thus-obtained crude 2-n-pentyl-3-ethoxyacrolein are dissolved in a sodium ethylate solution (obtained from 580 mg. of sodium in 40 ml. of ethanol) and treated with 2.6 g. of the aforementioned 4'-bromo-4-biphenylamidine hydrochloride. The mixture is stirred at room temperature for 3 days. After some of the solvent has been distilled off, water is added and the mixture is extracted with chloroform in the usual manner. Upon crystallization from ethanol, there is obtained 5-n-pentyl-2-(4'-bromo-4-biphenylyl)-pyrimidine in the form of needles, having a melting point of 137° C. and a clearing point of 197° C.

Workup

  1. additiontreated with 2.6 g
  2. distillationAfter some of the solvent has been distilled off
  3. additionwater is added
  4. extractionthe mixture is extracted with chloroform in the usual manner
  5. customUpon crystallization from ethanol

Sources & evidence

ORD record
ord-bdb559cb11134fba9914415f8059c85d
Source dataset
uspto-grants-1982_01
Patent number
US04309539

Reaction notes

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