Chloroacetone → HCID 20524745, compound

HRID 1105707Notes

Reaction equation

HRID 1105707 reaction equation
[Cl:1][C:2]1[CH:12]=[CH:11][C:5]([NH:6][S:7]([CH3:10])(=[O:9])=[O:8])=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].Cl[CH2:20][C:21](=[O:23])[CH3:22]>COCCOC>[O:23]=[C:21]([CH3:22])[CH2:20][N:6]([S:7]([CH3:10])(=[O:9])=[O:8])[C:5]1[CH:11]=[CH:12][C:2]([Cl:1])=[CH:3][CH:4]=1

Participants

5

Reactant 3

HCID 6571ChloroacetoneHCID 11430Potassium CarbonateHCID 706838P-CHLORO METHANESULFONANILIDE

Product 1

HCID 20524745HCID 20524745, compound

Reagents, catalysts & solvents 1

HCID 80711,2-DimethoxyethaneSolvent

Procedure

A mixture of 4'-chloro-methanesulphonanilide (10.0 g), anhydrous potassium carbonate (4.0 g), chloroacetone (4.8 ml), and 1,2-dimethoxyethane was stirred and boiled under reflux for 24 hours, and then filtered, and the filtrate was evaporated. The oil residue was dissolved in ether, and the solution was washed with water, dried (MgSO4) and evaporated. The residue gave almost colourless crystals from acetone/40°-60° petrol. Melting point 108°. Yield 4.1 g.

Workup

  1. temperatureunder reflux for 24 hours
  2. filtrationfiltered
  3. customthe filtrate was evaporated
  4. dissolutionThe oil residue was dissolved in ether
  5. washthe solution was washed with water
  6. dry with materialdried (MgSO4)
  7. customevaporated
  8. customThe residue gave almost colourless crystals from acetone/40°-60° petrol

Sources & evidence

ORD record
ord-855232f3d9c042e0842580223ebe3997
Source dataset
uspto-grants-1982_01
Patent number
US04309559

Reaction notes

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