HCID 20555063, compound → HCID 20555100, compound

HRID 1105818Notes

Reaction equation

HRID 1105818 reaction equation
[C:1]([NH:5][CH2:6][CH:7]([OH:20])[CH2:8][O:9][C:10]1[CH:11]=[CH:12][CH:13]=[C:14]([NH2:19])[C:15]=1[C:16]([NH2:18])=O)([CH3:4])([CH3:3])[CH3:2].[H-].[Al+3].[Li+].[H-].[H-].[H-]>O1CCCC1>[NH2:18][CH2:16][C:15]1[C:10]([O:9][CH2:8][CH:7]([OH:20])[CH2:6][NH:5][C:1]([CH3:3])([CH3:2])[CH3:4])=[CH:11][CH:12]=[CH:13][C:14]=1[NH2:19]

Participants

4

Reactant 2

HCID 20555063HCID 20555063, compoundHCID 21226445Aluminium lithium hydride

Product 1

HCID 20555100HCID 20555100, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

12 g of crude 6-(3-tert.-butylamino-2-hydroxypropoxy)-anthranilamide are dissolved in 400 ml of tetrahydrofurane and reduced, analogously to Example 4(e), with 6.1 g of lithium aluminium hydride for 48 hours. After working up, 2-aminomethyl-3-(3-tert.-butylamino-2-hydroxy-propoxy)-aniline is obtained in the form of an oil which is further used as such. It forms a tri-hydrochloride with a melting point of 250°-260° (with sublimation).

Sources & evidence

ORD record
ord-ee8ef6e0cfae467eb4f0e32fc021836f
Source dataset
uspto-grants-1982_01
Patent number
US04310527

Reaction notes

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