Hydrogen Peroxide → Methyl 3-methylanthranilate
Reaction equation
OO.[CH3:3][C:4]1[CH:5]=[CH:6][CH:7]=[C:8]2[C:12]=1[NH:11]C(=O)C2=O.[CH3:15][O-:16].[Na+].[CH3:18][OH:19]>>[CH3:3][C:4]1[CH:5]=[CH:6][CH:7]=[C:8]([C:15]([O:19][CH3:18])=[O:16])[C:12]=1[NH2:11]Participants
5
Procedure
15 parts of 50 percent strength by weight hydrogen peroxide solution are added slowly to a solution of 32.2 parts of 7-methylisatin and 12 parts of sodium methylate in 400 parts of methanol at 0° C. Thereafter, the mixture is stirred for 2 hours at room temperature and worked up as described in Example 1. 25.5 parts (78% of theory) of methyl 3-methylanthranilate, of melting point 27°-29° C., are obtained.
Sources & evidence
- ORD record
- ord-28011baad564427db3a4301e2bb76d1b
- Source dataset
- uspto-grants-1982_01
- Patent number
- US04310677
Reaction notes
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