Hydrochloric Acid → HCID 20554507, compound

HRID 1106090Notes

Reaction equation

HRID 1106090 reaction equation
[NH2:1][CH2:2][CH:3]([OH:29])[CH2:4][NH:5][CH:6]([CH2:18][CH2:19][C:20]1[CH:25]=[CH:24][C:23]([CH:26]([CH3:28])[CH3:27])=[CH:22][CH:21]=1)[CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([CH:15]([CH3:17])[CH3:16])=[CH:11][CH:10]=1.[ClH:30]>C(O)(C)C>[OH2:29].[ClH:30].[ClH:30].[NH2:1][CH2:2][CH:3]([OH:29])[CH2:4][NH:5][CH:6]([CH2:18][CH2:19][C:20]1[CH:21]=[CH:22][C:23]([CH:26]([CH3:28])[CH3:27])=[CH:24][CH:25]=1)[CH2:7][CH2:8][C:9]1[CH:14]=[CH:13][C:12]([CH:15]([CH3:17])[CH3:16])=[CH:11][CH:10]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 12797297HCID 12797297, compound

Product 1

HCID 20554507HCID 20554507, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent2×

Procedure

To a cooled (ice-bath cooling) solution of 1-amino-3-{{3-[4-(1-methylethyl)phenyl]-1-{2-[4-(1-methylethyl)phenyl]ethyl}propyl}amino]-2-propanol in isopropanol (about 5 ml. of isopropanol for each gram of free base) is added anhydrous hydrogen chloride gas with stirring. When precipitation is complete, the resultant dihydrochloride is filtered. Recrystallization from isopropanol (95), water (5), (about 5 ml. of solvent for each gram of product) yields 1-amino-3-{{3-[4-(1-methylethyl)phenyl]-1-{2-[4-(1-methylethyl)phenyl]ethyl}propyl}amino]-2-propanol dihydrochloride monohydrate, m.p. 263°-265° C.

Workup

  1. temperatureTo a cooled
  2. customWhen precipitation
  3. filtrationthe resultant dihydrochloride is filtered
  4. customRecrystallization from isopropanol (95), water (5)

Sources & evidence

ORD record
ord-ea4ab00193884369a3ae732f4187ba33
Source dataset
uspto-grants-1982_01
Patent number
US04311709

Reaction notes

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